GlutaredoxinV1, Main, Exploration, bibRecord, 000234

Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Identifieur interne : 000234 ( Main/Exploration ); précédent : 000233; suivant : 000235

Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Auteurs : Anju Sreelatha [États-Unis] ; Samantha S. Yee [États-Unis] ; Victor A. Lopez [États-Unis] ; Brenden C. Park [États-Unis] ; Lisa N. Kinch [États-Unis] ; Sylwia Pilch [Pologne] ; Kelly A. Servage [États-Unis] ; Junmei Zhang [États-Unis] ; Jenny Jiou [États-Unis] ; Monika Karasiewicz-Urba Ska [Pologne] ; Małgorzata Łobocka [Pologne] ; Nick V. Grishin [États-Unis] ; Kim Orth [États-Unis] ; Roza Kucharczyk [Pologne] ; Krzysztof Pawłowski [Pologne] ; Diana R. Tomchick [États-Unis] ; Vincent S. Tagliabracci [États-Unis]

Source :

Cell [ 1097-4172 ] ; 2018.

RBID : pubmed:30270044

Descripteurs français

KwdFr :
- AMP (métabolisme), Domaine catalytique (MeSH), Humains (MeSH), Maturation post-traductionnelle des protéines (MeSH), Protéines mitochondriales (génétique), Protéines mitochondriales (métabolisme), Stress oxydatif (MeSH), Sélénoprotéines (composition chimique), Sélénoprotéines (métabolisme), Séquence conservée (MeSH).
MESH :
- composition chimique : Sélénoprotéines.
- génétique : Protéines mitochondriales.
- métabolisme : AMP, Protéines mitochondriales, Sélénoprotéines.
- Domaine catalytique, Humains, Maturation post-traductionnelle des protéines, Stress oxydatif, Séquence conservée.

English descriptors

KwdEn :
- Adenosine Monophosphate (metabolism), Catalytic Domain (MeSH), Conserved Sequence (MeSH), Humans (MeSH), Mitochondrial Proteins (genetics), Mitochondrial Proteins (metabolism), Oxidative Stress (MeSH), Protein Processing, Post-Translational (MeSH), Selenoproteins (chemistry), Selenoproteins (metabolism).
MESH :
- chemical , chemistry : Selenoproteins.
- chemical , genetics : Mitochondrial Proteins.
- chemical , metabolism : Adenosine Monophosphate, Mitochondrial Proteins, Selenoproteins.
- Catalytic Domain, Conserved Sequence, Humans, Oxidative Stress, Protein Processing, Post-Translational.

Abstract

Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here, we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation), uncovering a previously unrecognized activity for a member of the protein kinase superfamily. The crystal structure of a SelO homolog reveals a protein kinase-like fold with ATP flipped in the active site, thus providing a structural basis for catalysis. SelO pseudokinases localize to the mitochondria and AMPylate proteins involved in redox homeostasis. Consequently, SelO activity is necessary for the proper cellular response to oxidative stress. Our results suggest that AMPylation may be a more widespread post-translational modification than previously appreciated and that pseudokinases should be analyzed for alternative transferase activities.

DOI: 10.1016/j.cell.2018.08.046
PubMed: 30270044
PubMed Central: PMC6524645

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000205
to stream Main, to step Curation: 000205

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protein AMPylation by an Evolutionarily Conserved Pseudokinase.</title>
<author><name sortKey="Sreelatha, Anju" sort="Sreelatha, Anju" uniqKey="Sreelatha A" first="Anju" last="Sreelatha">Anju Sreelatha</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yee, Samantha S" sort="Yee, Samantha S" uniqKey="Yee S" first="Samantha S" last="Yee">Samantha S. Yee</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Victor A" sort="Lopez, Victor A" uniqKey="Lopez V" first="Victor A" last="Lopez">Victor A. Lopez</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Park, Brenden C" sort="Park, Brenden C" uniqKey="Park B" first="Brenden C" last="Park">Brenden C. Park</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kinch, Lisa N" sort="Kinch, Lisa N" uniqKey="Kinch L" first="Lisa N" last="Kinch">Lisa N. Kinch</name>
<affiliation wicri:level="2"><nlm:affiliation>Howard Hughes Medical Institute, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilch, Sylwia" sort="Pilch, Sylwia" uniqKey="Pilch S" first="Sylwia" last="Pilch">Sylwia Pilch</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106</wicri:regionArea>
<wicri:noRegion>Warsaw 02-106</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Servage, Kelly A" sort="Servage, Kelly A" uniqKey="Servage K" first="Kelly A" last="Servage">Kelly A. Servage</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Junmei" sort="Zhang, Junmei" uniqKey="Zhang J" first="Junmei" last="Zhang">Junmei Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiou, Jenny" sort="Jiou, Jenny" uniqKey="Jiou J" first="Jenny" last="Jiou">Jenny Jiou</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karasiewicz Urba Ska, Monika" sort="Karasiewicz Urba Ska, Monika" uniqKey="Karasiewicz Urba Ska M" first="Monika" last="Karasiewicz-Urba Ska">Monika Karasiewicz-Urba Ska</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lobocka, Malgorzata" sort="Lobocka, Malgorzata" uniqKey="Lobocka M" first="Małgorzata" last="Łobocka">Małgorzata Łobocka</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grishin, Nick V" sort="Grishin, Nick V" uniqKey="Grishin N" first="Nick V" last="Grishin">Nick V. Grishin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orth, Kim" sort="Orth, Kim" uniqKey="Orth K" first="Kim" last="Orth">Kim Orth</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kucharczyk, Roza" sort="Kucharczyk, Roza" uniqKey="Kucharczyk R" first="Roza" last="Kucharczyk">Roza Kucharczyk</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106</wicri:regionArea>
<wicri:noRegion>Warsaw 02-106</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pawlowski, Krzysztof" sort="Pawlowski, Krzysztof" uniqKey="Pawlowski K" first="Krzysztof" last="Pawłowski">Krzysztof Pawłowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomchick, Diana R" sort="Tomchick, Diana R" uniqKey="Tomchick D" first="Diana R" last="Tomchick">Diana R. Tomchick</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tagliabracci, Vincent S" sort="Tagliabracci, Vincent S" uniqKey="Tagliabracci V" first="Vincent S" last="Tagliabracci">Vincent S. Tagliabracci</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: vincent.tagliabracci@utsouthwestern.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390</wicri:regionArea>
<wicri:noRegion>Texas 75390</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:30270044</idno>
<idno type="pmid">30270044</idno>
<idno type="doi">10.1016/j.cell.2018.08.046</idno>
<idno type="pmc">PMC6524645</idno>
<idno type="wicri:Area/Main/Corpus">000205</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000205</idno>
<idno type="wicri:Area/Main/Curation">000205</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000205</idno>
<idno type="wicri:Area/Main/Exploration">000205</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Protein AMPylation by an Evolutionarily Conserved Pseudokinase.</title>
<author><name sortKey="Sreelatha, Anju" sort="Sreelatha, Anju" uniqKey="Sreelatha A" first="Anju" last="Sreelatha">Anju Sreelatha</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yee, Samantha S" sort="Yee, Samantha S" uniqKey="Yee S" first="Samantha S" last="Yee">Samantha S. Yee</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Victor A" sort="Lopez, Victor A" uniqKey="Lopez V" first="Victor A" last="Lopez">Victor A. Lopez</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Park, Brenden C" sort="Park, Brenden C" uniqKey="Park B" first="Brenden C" last="Park">Brenden C. Park</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kinch, Lisa N" sort="Kinch, Lisa N" uniqKey="Kinch L" first="Lisa N" last="Kinch">Lisa N. Kinch</name>
<affiliation wicri:level="2"><nlm:affiliation>Howard Hughes Medical Institute, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Howard Hughes Medical Institute, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilch, Sylwia" sort="Pilch, Sylwia" uniqKey="Pilch S" first="Sylwia" last="Pilch">Sylwia Pilch</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106</wicri:regionArea>
<wicri:noRegion>Warsaw 02-106</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Servage, Kelly A" sort="Servage, Kelly A" uniqKey="Servage K" first="Kelly A" last="Servage">Kelly A. Servage</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Junmei" sort="Zhang, Junmei" uniqKey="Zhang J" first="Junmei" last="Zhang">Junmei Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiou, Jenny" sort="Jiou, Jenny" uniqKey="Jiou J" first="Jenny" last="Jiou">Jenny Jiou</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karasiewicz Urba Ska, Monika" sort="Karasiewicz Urba Ska, Monika" uniqKey="Karasiewicz Urba Ska M" first="Monika" last="Karasiewicz-Urba Ska">Monika Karasiewicz-Urba Ska</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lobocka, Malgorzata" sort="Lobocka, Malgorzata" uniqKey="Lobocka M" first="Małgorzata" last="Łobocka">Małgorzata Łobocka</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grishin, Nick V" sort="Grishin, Nick V" uniqKey="Grishin N" first="Nick V" last="Grishin">Nick V. Grishin</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orth, Kim" sort="Orth, Kim" uniqKey="Orth K" first="Kim" last="Orth">Kim Orth</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kucharczyk, Roza" sort="Kucharczyk, Roza" uniqKey="Kucharczyk R" first="Roza" last="Kucharczyk">Roza Kucharczyk</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106</wicri:regionArea>
<wicri:noRegion>Warsaw 02-106</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pawlowski, Krzysztof" sort="Pawlowski, Krzysztof" uniqKey="Pawlowski K" first="Krzysztof" last="Pawłowski">Krzysztof Pawłowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776</wicri:regionArea>
<wicri:noRegion>Warsaw 02-776</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomchick, Diana R" sort="Tomchick, Diana R" uniqKey="Tomchick D" first="Diana R" last="Tomchick">Diana R. Tomchick</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tagliabracci, Vincent S" sort="Tagliabracci, Vincent S" uniqKey="Tagliabracci V" first="Vincent S" last="Tagliabracci">Vincent S. Tagliabracci</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: vincent.tagliabracci@utsouthwestern.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390</wicri:regionArea>
<wicri:noRegion>Texas 75390</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell</title>
<idno type="eISSN">1097-4172</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Monophosphate (metabolism)</term>
<term>Catalytic Domain (MeSH)</term>
<term>Conserved Sequence (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Mitochondrial Proteins (genetics)</term>
<term>Mitochondrial Proteins (metabolism)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Protein Processing, Post-Translational (MeSH)</term>
<term>Selenoproteins (chemistry)</term>
<term>Selenoproteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>AMP (métabolisme)</term>
<term>Domaine catalytique (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Maturation post-traductionnelle des protéines (MeSH)</term>
<term>Protéines mitochondriales (génétique)</term>
<term>Protéines mitochondriales (métabolisme)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Sélénoprotéines (composition chimique)</term>
<term>Sélénoprotéines (métabolisme)</term>
<term>Séquence conservée (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Selenoproteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mitochondrial Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Mitochondrial Proteins</term>
<term>Selenoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Sélénoprotéines</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines mitochondriales</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP</term>
<term>Protéines mitochondriales</term>
<term>Sélénoprotéines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Catalytic Domain</term>
<term>Conserved Sequence</term>
<term>Humans</term>
<term>Oxidative Stress</term>
<term>Protein Processing, Post-Translational</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Domaine catalytique</term>
<term>Humains</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Stress oxydatif</term>
<term>Séquence conservée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here, we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation), uncovering a previously unrecognized activity for a member of the protein kinase superfamily. The crystal structure of a SelO homolog reveals a protein kinase-like fold with ATP flipped in the active site, thus providing a structural basis for catalysis. SelO pseudokinases localize to the mitochondria and AMPylate proteins involved in redox homeostasis. Consequently, SelO activity is necessary for the proper cellular response to oxidative stress. Our results suggest that AMPylation may be a more widespread post-translational modification than previously appreciated and that pseudokinases should be analyzed for alternative transferase activities.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30270044</PMID>
<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>175</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>10</Month>
<Day>18</Day>
</PubDate>
</JournalIssue>
<Title>Cell</Title>
<ISOAbbreviation>Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>Protein AMPylation by an Evolutionarily Conserved Pseudokinase.</ArticleTitle>
<Pagination><MedlinePgn>809-821.e19</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0092-8674(18)31107-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2018.08.046</ELocationID>
<Abstract><AbstractText>Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here, we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation), uncovering a previously unrecognized activity for a member of the protein kinase superfamily. The crystal structure of a SelO homolog reveals a protein kinase-like fold with ATP flipped in the active site, thus providing a structural basis for catalysis. SelO pseudokinases localize to the mitochondria and AMPylate proteins involved in redox homeostasis. Consequently, SelO activity is necessary for the proper cellular response to oxidative stress. Our results suggest that AMPylation may be a more widespread post-translational modification than previously appreciated and that pseudokinases should be analyzed for alternative transferase activities.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sreelatha</LastName>
<ForeName>Anju</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yee</LastName>
<ForeName>Samantha S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lopez</LastName>
<ForeName>Victor A</ForeName>
<Initials>VA</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Brenden C</ForeName>
<Initials>BC</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kinch</LastName>
<ForeName>Lisa N</ForeName>
<Initials>LN</Initials>
<AffiliationInfo><Affiliation>Howard Hughes Medical Institute, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pilch</LastName>
<ForeName>Sylwia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Servage</LastName>
<ForeName>Kelly A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Junmei</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiou</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karasiewicz-Urbańska</LastName>
<ForeName>Monika</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Łobocka</LastName>
<ForeName>Małgorzata</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grishin</LastName>
<ForeName>Nick V</ForeName>
<Initials>NV</Initials>
<AffiliationInfo><Affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Orth</LastName>
<ForeName>Kim</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kucharczyk</LastName>
<ForeName>Roza</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pawłowski</LastName>
<ForeName>Krzysztof</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tomchick</LastName>
<ForeName>Diana R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tagliabracci</LastName>
<ForeName>Vincent S</ForeName>
<Initials>VS</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: vincent.tagliabracci@utsouthwestern.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>T32 DK007257</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><Acronym>HHMI</Acronym>
<Agency>Howard Hughes Medical Institute</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM094575</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R00 DK099254</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 GM008203</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM115188</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>09</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Cell</MedlineTA>
<NlmUniqueID>0413066</NlmUniqueID>
<ISSNLinking>0092-8674</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D024101">Mitochondrial Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051140">Selenoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>415SHH325A</RegistryNumber>
<NameOfSubstance UI="D000249">Adenosine Monophosphate</NameOfSubstance>
</Chemical>
</ChemicalList>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cell. 2018 Oct 18;175(3):641-642</RefSource>
<PMID Version="1">30340038</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Curr Biol. 2019 Jan 7;29(1):R23-R25</RefSource>
<PMID Version="1">30620911</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000249" MajorTopicYN="N">Adenosine Monophosphate</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020134" MajorTopicYN="Y">Catalytic Domain</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017124" MajorTopicYN="N">Conserved Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024101" MajorTopicYN="N">Mitochondrial Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011499" MajorTopicYN="Y">Protein Processing, Post-Translational</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051140" MajorTopicYN="N">Selenoproteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">SELENOO</Keyword>
<Keyword MajorTopicYN="Y">adenylylation</Keyword>
<Keyword MajorTopicYN="Y">glutaredoxin</Keyword>
<Keyword MajorTopicYN="Y">glutathionylation</Keyword>
<Keyword MajorTopicYN="Y">kinase structure</Keyword>
<Keyword MajorTopicYN="Y">oxidative stress</Keyword>
<Keyword MajorTopicYN="Y">selenocysteine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>03</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>07</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>08</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>10</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>7</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>10</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30270044</ArticleId>
<ArticleId IdType="pii">S0092-8674(18)31107-3</ArticleId>
<ArticleId IdType="doi">10.1016/j.cell.2018.08.046</ArticleId>
<ArticleId IdType="pmc">PMC6524645</ArticleId>
<ArticleId IdType="mid">NIHMS1013863</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>FEBS Lett. 2008 Apr 30;582(10):1558-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18405665</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Struct Biol. 2010 Dec;20(6):772-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21074407</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2015 Jul 1;43(W1):W30-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25943547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 Jun 18;161(7):1619-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26091039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2010 Aug 20;329(5994):946-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20651120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2002 Dec 6;298(5600):1912-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12471243</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Res. 2011 Jan;45(1):29-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21110783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2018 Jan 25;172(3):409-422.e21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29290465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2010 Jul;38(Web Server issue):W545-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20457744</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Apr 21;9(4):e95518</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24751718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Soc Trans. 2013 Aug;41(4):981-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23863167</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011 Apr 27;6(4):e18910</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21556138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Elife. 2016 Nov 23;5:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27879205</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2013 Jan 11;430(2):865-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23058924</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Apr 13;282(15):10853-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17261589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1995 Jul 27;376(6538):313-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7630397</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2010 Aug;17(8):1004-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20622875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2013 Apr;30(4):772-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23329690</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2009 Jun 05;4(6):e5818</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19503829</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yeast. 1998 Jul;14(10):953-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9717241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):426-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20382996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20057044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2013;4:2973</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24346350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2007 May 4;368(3):639-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17367808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Rev. 2018 Feb 14;118(3):1199-1215</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28819965</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Jul 13;287(29):24304-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22661713</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Soc Trans. 2013 Aug;41(4):969-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23863165</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vis Exp. 2010 Mar 30;(37):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20354502</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Elife. 2015 Mar 19;4:e06120</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25789606</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2008 Dec 1;24(23):2780-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18818215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):348-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15706083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 1998 May;9(5):1081-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9571241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Protoc Protein Sci. 2013 Nov 05;74:19.23.1-19.23.14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24510646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Oncol. 2012 Jun 20;2:64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22737670</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Future Med Chem. 2017 Jan;9(2):245-265</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28097887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21608-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20007378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Nov 18;310(5751):1152-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16254148</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10829079</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1439-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12775843</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Chem Soc. 2014 Jul 2;136(26):9338-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24950229</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20383002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2003 Nov;59(Pt 11):2031-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14573959</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 1995 Sep;20(9):345-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7482698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2015 Feb 15;466(1):201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25656056</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 Jun 25;285(26):20155-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20410310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2004 Jun;14(6):1188-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15173120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2016 Jan 5;24(1):7-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26745528</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr A. 2003 May;59(Pt 3):228-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12714773</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2006 Aug;62(Pt 8):859-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16855301</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2007 Sep 7;27(5):717-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17803937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20124702</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3482-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27185916</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 1999;115:11-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10098159</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol. 2011 Aug 26;18(8):1011-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21867916</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(2):e32138</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22359664</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Jun 1;336(6085):1150-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22582013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1997 Jun 30;410(2-3):219-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9237633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biotechnol. 2011 Feb 10;151(3):251-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21185336</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Jun 28;8(6):e66427</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23840464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2015 Aug 21;290(34):20804-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26085103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2016 Jan 4;44(D1):D279-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26673716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004 Oct 12;32(18):5452-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15479782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1997 Sep 1;25(17):3389-402</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9254694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 2011 Feb;36(2):65-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20971646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Immunol. 2002 Feb;38(10):773-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11841837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2014 Jan;42(Database issue):D297-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24319143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Chem Biol. 2010 Mar;6(3):166-169</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20154661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Structure. 2004 Jul;12(7):1303-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15242606</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Chem Biol. 2013 Dec;9(12):811-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24141193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2009 Aug;11(8):1819-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19361272</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2012 Mar 15;16(6):471-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22136616</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Physiol Rev. 2014 Jul;94(3):739-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24987004</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Synchrotron Radiat. 2013 Jan;20(Pt 1):37-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23254654</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Mol Biol Int. 1998 Apr;44(4):747-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9584988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1974 Mar 8;183(4128):915-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4605100</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7692-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20351256</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Vis Exp. 2009 Aug 24;(30):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19704406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2010 Oct;13(8):1205-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20136512</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Pologne</li>
<li>États-Unis</li>
</country>
<region><li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Sreelatha, Anju" sort="Sreelatha, Anju" uniqKey="Sreelatha A" first="Anju" last="Sreelatha">Anju Sreelatha</name>
</region>
<name sortKey="Grishin, Nick V" sort="Grishin, Nick V" uniqKey="Grishin N" first="Nick V" last="Grishin">Nick V. Grishin</name>
<name sortKey="Jiou, Jenny" sort="Jiou, Jenny" uniqKey="Jiou J" first="Jenny" last="Jiou">Jenny Jiou</name>
<name sortKey="Kinch, Lisa N" sort="Kinch, Lisa N" uniqKey="Kinch L" first="Lisa N" last="Kinch">Lisa N. Kinch</name>
<name sortKey="Lopez, Victor A" sort="Lopez, Victor A" uniqKey="Lopez V" first="Victor A" last="Lopez">Victor A. Lopez</name>
<name sortKey="Orth, Kim" sort="Orth, Kim" uniqKey="Orth K" first="Kim" last="Orth">Kim Orth</name>
<name sortKey="Park, Brenden C" sort="Park, Brenden C" uniqKey="Park B" first="Brenden C" last="Park">Brenden C. Park</name>
<name sortKey="Servage, Kelly A" sort="Servage, Kelly A" uniqKey="Servage K" first="Kelly A" last="Servage">Kelly A. Servage</name>
<name sortKey="Tagliabracci, Vincent S" sort="Tagliabracci, Vincent S" uniqKey="Tagliabracci V" first="Vincent S" last="Tagliabracci">Vincent S. Tagliabracci</name>
<name sortKey="Tomchick, Diana R" sort="Tomchick, Diana R" uniqKey="Tomchick D" first="Diana R" last="Tomchick">Diana R. Tomchick</name>
<name sortKey="Yee, Samantha S" sort="Yee, Samantha S" uniqKey="Yee S" first="Samantha S" last="Yee">Samantha S. Yee</name>
<name sortKey="Zhang, Junmei" sort="Zhang, Junmei" uniqKey="Zhang J" first="Junmei" last="Zhang">Junmei Zhang</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Pilch, Sylwia" sort="Pilch, Sylwia" uniqKey="Pilch S" first="Sylwia" last="Pilch">Sylwia Pilch</name>
</noRegion>
<name sortKey="Karasiewicz Urba Ska, Monika" sort="Karasiewicz Urba Ska, Monika" uniqKey="Karasiewicz Urba Ska M" first="Monika" last="Karasiewicz-Urba Ska">Monika Karasiewicz-Urba Ska</name>
<name sortKey="Kucharczyk, Roza" sort="Kucharczyk, Roza" uniqKey="Kucharczyk R" first="Roza" last="Kucharczyk">Roza Kucharczyk</name>
<name sortKey="Lobocka, Malgorzata" sort="Lobocka, Malgorzata" uniqKey="Lobocka M" first="Małgorzata" last="Łobocka">Małgorzata Łobocka</name>
<name sortKey="Pawlowski, Krzysztof" sort="Pawlowski, Krzysztof" uniqKey="Pawlowski K" first="Krzysztof" last="Pawłowski">Krzysztof Pawłowski</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/GlutaredoxinV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000234 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000234 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    GlutaredoxinV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30270044
   |texte=   Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30270044" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GlutaredoxinV1

This area was generated with Dilib version V0.6.37.
Data generation: Wed Nov 18 15:13:42 2020. Site generation: Wed Nov 18 15:16:12 2020

	Serveur d'exploration sur la glutarédoxine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la glutarédoxine

Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki